It also revealed CRNDE interacts with specific mRNAs dysregulated in cancer progression such as CDK6, PTEN, ALKBH5, IGF1R etc. Among the dysregulated mRNA such as ZEB1, PTEN and MEF2C are known to be specifically involved in T-ALL pathogenesis (Fig. 2C). Here, IGF1R is linked to acute lymphoblastic leukemia.