A study by Shehata et al. aimed to check the role of CRNDE in chronic lymphocytic leukemia (CML) and showed that CRNDE is downregulated in CML patients and is associated with poor prognostic markers such as high levels of serum beta-2 microglobulin and lactic dehydrogenase, and the presence of del17p [40]. Here, B2M is linked to chronic myelogenous leukemia, BCR-ABL1 positive.