We screened all the exons of 12 lipid metabolism-related genes (ANGPTL3, ANGPTL4, APOA1, APOA5, APOC1, APOC3, CETP, LDLR, LIPC, LPL, PCSK9 and SCARB1) and their flanking sequences in 120 CAD patients and 132 control individuals. The gene discussed is APOA1; the disease is coronary artery disorder.