Increased expression of AQP4 in CNS tumours was related to considerable peritumoral oedema, as shown by Ng et al. The ablation of AQP4 in astroglial cells greatly inhibited cell motility more towards a stab injury in adult mouse brain, and glial wound development was disrupted in AQP4-null animals, with decreased migration of reactive astroglia toward a spot of brain damage [13, 140]. Here, AQP4 is linked to central nervous system neoplasm.