A research of AQP3-deficient mice indicated that AQP3-deficient animals are resilient to the advancement of melanoma owing to a reduced concentration of glycerol in cells and ATP energy for biogenesis [113, 116], and that AQP3 was essential for skin tumour growth, as AQP3-deficient animals could not form skin tumours when exposed to a tumour initiator [116]. Here, AQP3 is linked to melanoma.