In another study, the active phosphorylated proteins extracellular signal-related kinase (ERK), protein kinase B (Akt), focal adhesion kinase (FAK), nuclear factor kappa light chain enhancer of activated B cells (NF-kB), and Src protein tyrosine kinase decreased when AQP3 was experimentally knocked down in breast cancer MDA-IBC-3 cell lines [133].. The gene discussed is AQP3; the disease is breast carcinoma.