In a multivariate logistic model IL-6 (OR: 1.021, 95% CI 1.010–1.033, p < 0.001), bio-ADM (OR: 1.021, 95% CI 1.003–1.040, p = 0.021) and creatinine (OR: 0.522, 95% CI 0.300–0.909, p = 0.022) were independent significant predictors in the COVID-19 cohort regarding the composite endpoint, in contrast to leukocytes, CRP and DPP3 (each p = n.s). Here, DPP3 is linked to COVID-19.