It was shown that subjects with detectable hs-cTnT (HR, 1.47; 95% CI, 1.21–1.77; p 0.001) and detectable CAC (HR, 2.35; 95% confidence interval [CI], 2.0 -2.76; p 0.001) possessed increased rates of ASCVD compared with undetectable findings. The gene discussed is TNNT2; the disease is atherosclerosis.