YAP1 and cystic fibrosis: Among typical features of the epithelial–mesenchymal transition, the loss of E-cadherin and claudins (LeSimple et al, 2010; Nilsson et al, 2010; Castellani et al, 2012; Ruan et al, 2014; Simonin et al, 2022) and abnormal regulation of TWIST1 and YAP1 (Quaresma et al, 2020, 2022) were reported in CF HAEC models.