YAP1 and cystic fibrosis: Although the different outcomes may be due to the cell models and/or the experimental conditions used, that is, CFBE or 16HBE cells expressing wild-type or F508del-CFTR grown under submerged conditions as compared to CFTR-CTL and CFTR-KD Calu-3 cells polarized at ALI, the two studies indicate that Hippo/YAP signaling is dysregulated in CF HAECs.