RHOH and diffuse large B-cell lymphoma: According to a study by Pasqualucci et al, they have reported that an aberrant hypermutation activity targets multiple loci, including the proto-oncogenes PIM1, MYC, RhoH/TTF (ARHH), and PAX5, in more than 50% of diffuse large-cell lymphomas, which are tumors derived from germinal centers.[45] Overall, the results indicate that the hypermutation of PIM1, MYC, RhoH/TTF, and PAX5 is not common to all germinal-center-derived tumors, but is instead largely restricted to DLBCL and alter-natively, different mutated genes may be selected in different lymphoma types.[45]