MYD88 and B-cell non-Hodgkin lymphoma: Since the MYD88 mutation is present in several B-cell lymphomas, it has been hypothesized that the MYD88 mutation represents an early molecular event of lymphomagenesis.[38] A study by Fujiishi et al did not detect the mutation in a diagnostic biopsy specimen of a patient with DLBCL, although the postmortem sample of a patient with DLBCL tested positive for the mutation.