The study by Amary et al in the Journal of Pathology (2011) that states “IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrigenase 2) mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumors” stands out with 676 citations. The gene discussed is IDH2; the disease is chondrosarcoma.