Moreover, we found that the conversion status of HR was mainly changed from positive status to negative status, accounting for 70.8% of 24 HR conversion cases, consistent with a prospective study conducted by Jin et al[19] In addition, a phenomenon was found in more than half of luminal B BC patients by Sebastian et al[40] that Ki67 expression by more than 50% has reduced to less than 15% after NAC. The gene discussed is MKI67; the disease is breast cancer.