Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are contraindicated during pregnancy due to their teratogenic effects, especially in the cardiovascular and central nervous systems, and may increase the risk of stillbirth.[6] Diuretics are generally used as second-line therapy for gestational hypertension,[4] and to date, there is no definite evidence that they can increase the risk of pregnancy. The gene discussed is ACE; the disease is preeclampsia.