TNF and early-onset autosomal dominant Alzheimer disease: Additionally, the top 20 KEGG pathways based on P values included predominantly Lipid and atherosclerosis, Chemical carcinogenesis - receptor activation, Fluid shear stress and atherosclerosis, Alzheimer’s disease, Kaposi sarcoma-associated herpesvirus infection, the phosphatidylinositol 3 kinase (PI3K)-Akt, AGE-RAGE signaling pathway in diabetic complications, Measles, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, interleukin (IL)-17, and tumor necrosis factor (TNF) signaling pathways and apoptosis (Fig. 5).