Gao et al designed RCT to explore the effect of Huoxue Huashi Decoction (Rhizoma Imperatae, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Rubra, Semen Phaseoli, Radix et Rhizoma Rhei, Radix Codonopsis, Poria, Flos Carthami, Herba Leonuri, Herba Artemisiae Scopariae, Stigma Maydis, Herba Lycopi, and Fructus Gardeniae) targeting TP53 on M2 macrophage polarization and NSCLC cell invasion.[79] TP53, the target of Huoxue Huashi Decoction in the treatment of NSCLC, was screened by network pharmacology analysis. The gene discussed is TP53; the disease is non-small cell lung carcinoma.