TP53 and stomach polyp: This susceptibility may be related to the reflux of bile into the stomach, which can disrupt lysosomal membranes, dissolve lipoproteins, and compromise the integrity of the gastric mucosal barrier.[14–16] In terms of genetics and other factors, studies found that gastric polyps occurrence and carcinogenesis connect mutations of tumor suppressor gene p53 and RAS, abnormal expression of tumor suppressor genes Ki67 and p16 and abnormal transduction pathways.[17–19] Logistic regression analysis showed that gender and age were also risk factors for gastric polyps.