SQLE and Alzheimer disease: The SQLE gene is also a member of the sterol regulatory element-binding protein (SREBP) pathway, which regulates cholesterol metabolism in response to cellular demand.[10] Dysregulation of the SREBP pathway has been associated with various diseases, including metabolic disorders and cancer.[11] SQLE has been implicated in the pathogenesis of several important diseases, including atherosclerosis and Alzheimer’s disease.