Overexpression of SQLE has been observed in several cancer types, including head and neck squamous cell carcinoma (HNSC), pancreatic adenocarcinoma, glioblastoma, colorectal cancer, and breast cancer (BRCA).[16–20] In addition, SQLE has been shown to play a critical role in promoting cancer cell survival and proliferation by modulating cholesterol metabolism and lipid signaling pathways.[10] In sarcoma, a rare type of cancer arising from connective tissues, the role of SQLE remains poorly understood. Here, SQLE is linked to colorectal cancer.