In the context of cancer, CCR7 has been reported to play a dual role, either promoting antitumor immunity by enhancing T cell activation or facilitating immune evasion by promoting lymphatic metastasis.[58] The observed negative correlation between SQLE and CCL19, CX3CL1, CCR2, and CCR7 suggests that SQLE overexpression in sarcoma may lead to a reduced expression of these chemokines and chemokine receptors, potentially affecting immune cell recruitment and infiltration in the TME. This evidence concerns the gene CX3CL1 and cancer.