SQLE and colorectal cancer: For example, studies have shown that SQLE is overexpressed in certain types of cancer, including HNSC, pancreatic adenocarcinoma, glioblastoma, colorectal cancer, and BRCA.[16–20] In these cancers, SQLE may contribute to the growth and survival of cancer cells by promoting cholesterol biosynthesis and altering signaling pathways.[29] However, there are no reports of SQLE in sarcoma.