CD160 is a glycoprotein expressed on the surface of various immune cells, including cytotoxic T cells, natural killer (NK) cells, and subsets of Tregs.[39] CD160 has been shown to regulate the activation, proliferation, and cytotoxicity of immune cells through its interaction with classical and nonclassical major histocompatibility complex molecules[40] In the context of cancer, CD160 can promote antitumor immunity by enhancing the cytotoxic activity of T cells and NK cells. This evidence concerns the gene CD160 and cancer.