Solute Carrier Family 5 Member 2 (SLC5A2, also named SGLT2), is responsible for reabsorption of the filtered glucose mostly and associated with familial renal glucosuria.[42] SGLT2 inhibitor could reduce inflammatory and oxidative stress pathways through inducing systematic and glomerular hemodynamic changes.[43] This suggested that TwHF might mediate SLC5A2 leading to renal inflammatory response then to KI, which need further study. This evidence concerns the gene PSME3 and familial renal glucosuria.