Several studies had shown that the expression levels of EME2 and USP24 were significantly higher in SMZL patients than in other B-cell lymphomas.[11] Cytogenetically, 7q deletion, trisomy 3, and 12q amplification were found in patients with SMZL,[12] while 6q21 deletion was observed in LPL/WM.[13] Pathologically, the bone marrow tissue of the patients with SMZL appeared intrasinusoidal infiltration of CD20 + cells, while the invasion of the bone marrow commonly manifested as paratrabecula in LPL/WM. Here, EME2 is linked to B-cell non-Hodgkin lymphoma.