Moreover, some data revealed that the incidence of intrasinusoidal infiltration of CD20 + cells in bone marrow tissue of the patients with SMZL was approximately 30%.[6] The intrasinusoidal infiltration, serving as a characteristic pathological feature, occurred predominantly in the early stage of the disease and developed into nodular interstitial infiltration in the later stages of the disease. Here, MS4A1 is linked to splenic marginal zone lymphoma.