Presence of the His194Arg variant is associated with decreased expression of ADM (adrenomedullin) and VEGF (vascular endothelial growth factor A), suggesting that rs570553380 may confer protection from pulmonary hypertension and right ventricular hypertrophy (59, 60), as recently demonstrated in a CRISPR mouse model (10). This evidence concerns the gene VEGFA and pulmonary arterial hypertension.