Earlier research has confirmed that in mesenteric arteries the pathogenesis leading to hypertension is largely determined by the downregulation of KV2.1 (Amberg et al., 2004) and/or KV1.5 (Sung et al., 2013; Bae et al., 2006) and a concurrent increase in the activity of CaV1.2 (Navedo et al., 2010) channels. The gene discussed is KCNA5; the disease is hypertensive disorder.