The recommended age of RRSO is 40 to 50 years for RAD51C and RAD51D PV carriers and age 45 to 50 years for BRIP1 PV carriers, with differences across guidelines.15,16,17 Our analysis supports the cost-effectiveness and undertaking of RRSO at age 45 years for RAD51C, RAD51D, and BRIP1 PV carriers to maximize QALYs and cancers prevented. Here, BRIP1 is linked to cancer.