Delaying surgery by 5 years for BRCA1 (RRM at age 35 years; RRSO at age 40 years) and BRCA2 (RRM at age 40 years; RRSO at age 45 years) was still cost-effective but with reduced QALYs and NMB and fewer cancers prevented. The gene discussed is BRCA2; the disease is cancer.