Compared with BC surveillance and medical prevention, undergoing both RRM and RRSO (at the same ages as in the base case) could prevent 536 BC cases and 387 OC cases along with 56 BC deaths and 246 OC deaths per 1000 BRCA1 PV carriers; 524 BC cases and 162 OC cases along with 67 BC deaths and 103 OC deaths per 1000 BRCA2 PV carriers; and 422 BC cases and 42 OC cases along with 102 BC deaths and 28 OC deaths per 1000 PALB2 PV carriers. Here, BRCA2 is linked to breast cancer.