NR-V04 treatment effectively inhibited tumor growth in the MC38 model (Fig. 7 A) and Yummer1.7 melanoma (generated from a tumor formed in a BrafV600/Cdkn2a−/−/Pten−/− mouse) (Fig. 7 B), as well as the commonly used B16F10 melanoma model (Fig. 7 C). This evidence concerns the gene PTEN and melanoma.