Mutant mice with low expression level of BubR1 (BubR1 hypomorphic or BubR1H/H mice) perform as one of classical models of progeria and display various significant abnormalities including cachectic dwarfism, fat loss, reduced stress tolerance, impaired wound healing, lordokyphosis, sarcopenia, cataracts, craniofacial dysmorphisms, arterial stiffening and shortened lifespan [32, 33]. This evidence concerns the gene BUB1B and progeroid syndrome.