Huang et al. found that lncRNA PTTG3P can promote the expression of PTTG1 followed by activating the Pl3K/AKT signaling pathway, then upregulating C-myc and cyclinD1, increasing the phosphorylation level of Rb protein, and finally promoting the proliferation of HCC cells [68]. Here, AKT1 is linked to hepatocellular carcinoma.