MEG3 and hepatocellular carcinoma: There is CpG hypermethylation in the CRE region of the MEG3 promoter in HCC cells, which affects the transcription of MEG3 to be down-regulated by 210-fold in HCC cells compared with non-malignant hepatocytes, and MEG3 can be used as a target molecule of miRNA-29 to regulate the growth of HCC cells [59].