GCG and Hypoglycemia: When hypoglycemia occurs, the hypothalamic-pituitary-adrenal axis (HPA axis), the body’s blood glucose counterregulatory mechanism, is activated, resulting in increased secretion of glucose-raising hormones, including glucagon, catecholamines, cortisol, and growth hormone, which raise blood glucose by regulating hepatic glycogenolysis and peripheral blood glucose utilization.