BCAR3 and cancer: miR-27a is one of the factors that its exact function in cancer is not certain and miR-27a-3p sponging by circ-BCAR3 results in esophageal tumor progression [182], while down-regulation of miR-27a and miR-27b by circ-0000994 results in pancreatic tumor suppression [183], confirming dual function of miR-27a in cancers.