Another study demonstrated that Z-ligustilide (Z-LIG), the main phthalide of Rhizoma chuanxiong, caused inhibition in the rate of proliferation and colony formation ability along with a concentration-dependent effect on apoptosis induction and restoration of Nur77 and Nor1 expression in AML cells by increasing the expression of Ace-H3. Here, NR4A1 is linked to acute myeloid leukemia.