Another study reported that in both AML cells and CD34(+)/38(−) AML LSCs, the inhibition of HDAC using a class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced the expression of activator protein 1, c-Jun and JunB as well as the death receptor TRAIL in both AML cells and CD34(+)/38(−) AML LSCs. The gene discussed is NR4A3; the disease is acute myeloid leukemia.