IL6 and plasma cell myeloma: An accumulating number of studies showed that the treatment of myeloma cell lines with 15d-PGJ2 and thiazolidinediones (rosiglitazone, pioglitazone, ciglitazone, and triglitazone) either alone or in combination resulted in induction of apoptosis by increased mitochondrial depolarization, and caspases activation, as well as a decrease in cell adhesion, IL-6 production, and NF-κB-dependent antiapoptotic proteins [143, 168–170].