Observed clearance changes of molecules with different molecular masses have been associated with an accumulation of middle-sized atherosclerosis-promoting proteins, but not with small molecules like creatinine.36 We could not find an association between low cystatin C/creatinine-based eGFR ratio and future cfPWV that could be similar to previously reported relationship with the cardiorenal syndrome.37 One explanation is the lack of cross-sectional data and the limited knowledge about events that could have affected the course of vascular aging. The gene discussed is CST3; the disease is atherosclerosis.