Emerging evidence hints that PYGB is involved in the tumorigeneses of different types of cancer, such as osteosarcoma [17], breast cancer [26], prostate cancer [29], colorectal cancer [33], gastric cancer [39], ovarian cancer [40], and non-small-cell lung cancer [41], as well as hepatocellular cancer [42]. This evidence concerns the gene PYGB and osteosarcoma.