Due to the small number of cases used in the studies, the many differences in the methods used in the studies, and the fact that the populations studied also have their own distinct geographical characteristics, these results are not universal, so there is currently insufficient evidence to support the use of PYGB as a definitive diagnostic indicator for preeclampsia or SPE, and the role of PYGB as a biomarker in hypertensive disorders complicated by pregnancy is limited. The gene discussed is PYGB; the disease is preeclampsia.