The detection of the PYGB expression levels in intestinal metaplasia cells in early-gastric-cancer tissues and further statistical analysis show that the positive rate of PYGB expression in intestinal metaplasia cells in early-gastric-cancer tissues is significantly higher in the multi-primary-lesion population than in the single-lesion population, suggesting that the detection of PYGB expression in intestinal metaplasia cells in locally resected early-gastric-cancer lesion tissues has a certain predictive value for judging whether multiple lesions still exist [45]. The gene discussed is PYGB; the disease is gastric cancer.