Similarly, earlier research has shown that berberine hinders lung cancer cell growth by affecting the matrix metalloproteinase 2 (MMP-2)/Bcl-2/Bax and Janus kinase 2 (Jak2)/vascular endothelial growth factor (VEGF)/NF-κB/AP-1 signaling pathways [50]. This evidence concerns the gene MMP2 and lung cancer.