TNF and triple-A syndrome: AAA has a complex multifactorial etiology, including inflammation, genetic factors or single nucleotide variants (SNV) of individual genes, as matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-13 (MMP-13) [6], interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) [7].