CNR2 and non-small cell lung carcinoma: Furthermore, cannabinoids have been shown to decrease the expression of the epidermal growth factor receptor (EGFR) as well as plasminogen activator inhibitor-1 (PAI-1) while increasing the expression of the tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) in non-small cell lung cancer (NSCLC) A549, H358, and H460 cell lines, and human-derived NSCLC cells via CB1, CB2, and TRPV1 [36].