Regarding epigenetic modifications that have been shown to be involved in the onset of GCA, hypomethylation of loci of genes encoding for proteins involved in T-cell receptor (TCR) activation, especially after interaction with the co-stimulatory molecule CD28 and of genes involved in the calcineurin-mediated intracellular pathway, which is critical for the induction of the nuclear transcription factor of activated T cells (NFAT), was observed in the arterial wall of GCA patients [30]. Here, CD28 is linked to temporal arteritis.