In addition to serving as a diagnostic and prognostic marker for primary cutaneous metastatic melanoma [7], mutations in the TRPM1 gene underlie several inherited eye disorders in humans, including night-blindness (nyctalopia), high myopia, and involuntary eye movements (strabismus, nystagmus), along with nyctalopia and leopard complex coat-spotting in Appaloosa horses [8,9,10,11]. This evidence concerns the gene TRPM1 and night blindness.