A missense mutation near the 5′-end of TRPM3 has been linked with autosomal dominant forms of cataract with or without glaucoma and anterior eye defects (e.g., persistent pupillary membrane) [52,53,54], and SNVs in TRPM3 have been associated with age-related nuclear cataract, incipient senile cataract, age-related macular degeneration (AMD), and glaucoma [55,56,57,58]. This evidence concerns the gene TRPM3 and senile cataract.