Recent publications conclude that quantifications of neurofilament light chain (NFL) in biofluids can be used to sensitively estimate neurodegeneration in rodent models of Creutzfeldt–Jakob disease [35], Huntington’s disease [36], and tauopathies [37], as well as in genetic models of synucleinopathies [38]. This evidence concerns the gene NEFL and synucleinopathy.