While one limitation of analyzing tissue in bulk is that it does not allow us to assign the changes in gene expression to certain cell types, it is an interesting notion that some of the most significantly changed genes in PFF-injected mice, e.g., Cst7, Itgax, Clec7a, and Lilrb4, are found to be expressed by disease-associated microglia in models of Alzheimer’s disease [51,52,53], suggesting that shared microglial responses exist between protein-misfolding diseases. Here, ITGAX is linked to early-onset autosomal dominant Alzheimer disease.