SOD1 and amyotrophic lateral sclerosis: Moreover, elevated activities of complexes II–III were noted in the motor cortex and cerebellum of patients with mutSOD1A4V as well as in the motor and parietal cortices and cerebellum of a single patient with mutSOD1Ill3T, with similar findings in the motor cortex and cerebellum of ALS patients without identified SOD1 mutations to date [46].