For instance, ALS patients with C9orf72 expansion exhibited p62 inclusions [281,282], and pathogenic mutations in SOD1 were found to lead to polyubiquitinated aggregates of misfolded mutSOD1 that interact with p62, thereby enhancing the association between mutSOD1 and microtubule-associated light chain 3-II (LC3-II), a primary autophagic marker embedded into autophagosomes [288,289]. This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.