While these NKAR-NK-92 and NKAR_RD-IL15-NK-92 cells were already active on their own against tumor cells expressing NKG2D ligands, specific lysis of murine glioblastoma cells employed as a model for NKG2DL-negative targets was only observed in the presence of a suitable NKAB molecule. The gene discussed is KLRK1; the disease is glioblastoma.