Therefore, agonists of α7 nAChRs, including nicotine, may be useful for treating AD, as the stimulation of nAChRs in the CNS regulates the release of different neurotransmitters, such as dopamine, glutamate, serotonin, norepinephrine and γ-aminobutyric acid [49]. Here, CHRNA7 is linked to Alzheimer disease.