By scRNA-Seq, Caronni and collaborators [19] discovered, in pancreatic ductal adenocarcinoma, the peculiar signature of the IL-1β-positive TAM subpopulation (IL1B+ TAM signature), a subset of macrophages enriched in genes of the inflammatory response (IL1B, TNF, NLRP3, PTGS2), of leukocyte recruitment (CXCL1, CXCL2, CCL3), and of angiogenesis induction (VGFA, THBS1, PDGFB), but depleted in interferon response and antigen presentation genes. Here, IL1B is linked to pancreatic ductal adenocarcinoma.