In breast cancer, microenvironmental IL-1β of the bone metastatic niche or the endogenous production of IL-1β by breast cancer cells prompted breast cancer stem cells to form colonies through the activation of NF-kB and CREB signaling, Wnt ligand secretion, and autocrine Wnt signaling in tumor cells [21]. The gene discussed is NFKB1; the disease is breast carcinoma.