NLRP3 is the most commonly found chemotherapy-induced inflammasome, which may increase or reduce the anti-tumor effects of cytotoxic drugs depending on the balance between two effects: on one hand, immune cell activation and pyroptosis (an inflammatory type of programmed cell death involving the activity of caspase-1 and gasdermin) [71]; on the other hand, the IL-1β-induced M2 polarization of TAM and IL-1β-induced epithelial–mesenchymal transition, promoting invasion and metastasis. Here, IL1B is linked to neoplasm.