Cytotoxic drugs, including doxorubicin, daunorubicin, melphalan, gemcitabine, fluorouracil, cytarabine, methotrexate, paclitaxel, etoposide, vincristine, and cisplatin, can activate inflammasomes and IL-1β-related pathways in cancer cells but also in myeloid cells in the TME [70]. The gene discussed is IL1B; the disease is cancer.