A small molecule inhibitor, ABBV-CLS-484 [31], and a related compound-182 [32] inhibit PTPN1/PTPN2 with high selectivity over other phosphatases and mediate anti-tumour effects via direct effects on cancer cells and via the enhancement of NK and T cell recruitment and effector function within tumours (Table 1). The gene discussed is PTPN1; the disease is neoplasm.