Further understanding of the effect of dimer formation on the interaction with these cellular binding partners is of interest for studying these protein-related diseases, such as medulloblastoma in the case of JPO2 [42,43], MLL1-rearranged leukemia for MLL1 [8,34], Rett Syndrome in the case of MeCP2 [44,45], and autism spectrum disorder in the case of PogZ [24,46]. This evidence concerns the gene POGZ and Rett syndrome.