Downregulation of UCHL-1 (ubiquitin C-terminal hydrolase L1), PRKN (parkin RBR E3 ubiquitin protein ligase), SNCAIP (synuclein alpha interacting protein), and USP9Y (ubiquitin specific peptidase 9 Y-linked), all of which translate to proteins within the UPP, have been identified in DLB [78,79,80,81]. The gene discussed is PRKN; the disease is Lewy body dementia.