VANGL2 and breast cancer: There are also reports of VANGL2 in perinuclear endocytic vesicles in a variety of contexts including a breast cancer cell line, SKBR7 [4], hUVECs under low-fluid shear stress [5], in complexes with the cytoplasmic scaffold protein GIPC [6], and when induced by either the depletion of nucleocytoplasmic shuttling protein Dapper1 [7] or the Adaptor Protein-3 complex [8].