Additionally, other key genes, such as GATA6 (GATA binding protein 6), DR4 (death receptor 4), and CASP8 (caspase-8), which are involved in cell adhesion, apoptosis, and proliferation, respectively, exhibit prominent methylation alterations, further emphasizing their potential role in the molecular landscape of GBM subsets [18,19]. Here, CASP8 is linked to glioblastoma.