In motor neurons extracted from Sigmar1−/− knockout mouse embryos or in motor neurons treated with the SIGMAR1 antagonist, morphofunctional axonal degeneration occurred, but the sensory neurons and glial cells treated with the antagonist were not damaged, demonstrating their lower sensitivity to SIGMAR1 dysfunction and confirming the cytotype selectivity of the mutation, which has also been observed in humans ALS [25]. Here, SIGMAR1 is linked to amyotrophic lateral sclerosis.