In line with this, PMN of patients suffering from leukocyte adhesion deficiency (LAD)-1 due to impaired β2 integrin activity [123] (see Section 3.4.1) presented with impaired phagocytic activity that was mimicked by CD11b and CD18 blocking mAb, respectively [124]. Here, ITGB2 is linked to leukocyte adhesion deficiency 1.