HPSE and neoplasm: Taking into account that heparanase is contributed by both tumor cells and host immune cells, we applied mouse (Panc02) and human (MiaPaca-2, BxPC-3, AsPC-1) PDAC cells to examine the effect of compound XII in syngeneic (intact host immune system; C57BL/6) and non-syngeneic (impaired immune system; SCID/NOD) backgrounds, respectively.