Immunohistochemistry, in situ hybridization, PCR, and Western blot analysis have demonstrated that heparanase expression is enhanced in almost all cancers examined to date, including, for example, myeloma, mesothelioma, breast, ovarian, pancreatic, gastric, colon, bladder, brain, prostate, and liver cancers [5,6]. This evidence concerns the gene HPSE and cancer.