Taken together with previous in vivo experiments with wild-type SARS-CoV-2 and in vitro data on the neutralizing effect on various variants, including wild-type, Gamma, Delta, and Omicron BA.1 [22,23], this study shows the universality of the protective effect of ACE2 618-DDC-ABD against infection with different SARS-CoV-2 variants. This evidence concerns the gene ACE2 and infection.