In these terms, antibody-functionalized lanthanide-doped CaF2 biolabel for cancer cell targeting was synthesized by Sasidharan et al. They prepared monodispersed lanthanide (Eu3+) doped CaF2 nanoparticles and functionalized them with anti-EGFR through EDC-NHS coupling chemistry for specific binding to EGFR-overexpressing cells. This evidence concerns the gene EGFR and cancer.