Moreover, upon analyzing the TCGA database, which included 250 cancer patients treated with PD‐1/PD‐L1 inhibitors, the tumor microenvironment phenotype demonstrated a notable increase in PD‐1, TIM‐3, LAG3, TIGIT, T‐bet, and EOMES in tumors of obese patients. This evidence concerns the gene HAVCR2 and neoplasm.