Since the FAS pathway is a well‐known regulator of T cell‐mediated apoptosis in AML cells along with the deregulation of TRAIL signaling, our data suggest that PIEZO1 protects AML cells against FAS/TRAIL dependent apoptosis, to promote the survival and proliferation of AML cells.32, 33. Here, PIEZO1 is linked to acute myeloid leukemia.