We found that PIEZO1 expression dichotomized at median expression value was associated with some specific leukemia features such as a significantly higher marrow blast rate (Figure 1C), cytological immature AML subtypes (Figure 1D), favorable cytogenetics (Figure 1E), and favorable molecular profiles according to ELN 2017 classification (Figure 1F). Here, PIEZO1 is linked to acute myeloid leukemia.