Since (i) PIEZO1 senses mechanical forces and perception of the microenvironment is essential for AML cell survival and growth, (ii) its activation induces a calcium influx and calcium is essential for AML cell survival, we hypothesized the mechanosensor could play a role in the leukemogenesis of AML.19, 20, 21. The gene discussed is PIEZO1; the disease is acute myeloid leukemia.