IHC staining of the same specimens for DKK1 and αSMA revealed that in nonadvanced adenoma, αSMA stained at the DKK1‐staining site in the tumor stroma (Figure 2B‐a), whereas in advanced cancer, the staining sites did not match, and DKK1 tended to concentrate in the tumor adenoduct (Figure 2B‐b). This evidence concerns the gene ACTA1 and adenoma.